Disclaimer: The services and information provided here are for information purposes. Copyright © 2006 Health-Care-Tips.org. Bronchodilators; theophylline products; drugs that make breathing easier by relaxing and widening certain breathing passages (bronchial tubes) of the lung. Finally, xanthines may have antiinflammatory effects, either via release of antiinflammatory cytokines or modulation of gene transcription or activation of histone dacetylase. XANTHINE DERIVATIVES FOR USE AS DIURETICS (PAT - EP0667777) ADAMUS Stefan, GAIDA Wolfram, MEADE Christopher, KÜFNER-MÜHL Ulrike BOEHRINGER INGELHEIM INTERNATIONAL GmbH. Interaction of xanthine derivatives with binding site of P-gp is a question which could be solved by experiment; although, molecular modelling may clear up this matter. All rights reserved. The methylated xanthine compounds caffeine, theobromine, and theophylline and their derivatives are used in medicine for their bronchodilator effects. } } // not handled: JScript pre 1900. | Blood levels must be checked regularly to avoid underdosing and overdosing. // And months and day arrays Xanthine derivatives are present in coffee, tea and cocoa seeds. If stomach upset occurs, it … Methods: Plant extracts containing xanthine derivatives and three xanthine derivatives were topically applied to the dorsal skin of hairless mice, and the mice were exposed to a resemblance of solar ultraviolet irradiation at a dose of 13.0 J/cm 2 (UVA) for 15 weeks, five times a week on weekdays. Ticlopidine (Ticlid) troleandomycin (Tao) verapamil (eg, Verelan). There are multiple modes of action, and different drugs exert varying selectivities. Xanthine is involved in human physiology and is an intermediate in the production of uric acid. The increase in cAMP causes relaxation of bronchial smooth muscle. Brand interchange - Do not change from one brand of this drug to another without consulting your pharmacist or doctor. Be aware of drug interactions with cimetidine, oral contraceptives, allopurinol, certain antibiotics, influenza vaccine, others 2. There is a genetic disease of xanthine metabolism, xanthinuria, due to deficiency of an enzyme, xanthine dehydrogenase, needed to process xanthine in the body. It is claimed: 1. Derivatives of xanthine, known collectively as xanthines, are a group of alkaloids commonly used for their effects as mild stimulants and as bronchodilators, notably in treating the symptoms of asthma. this[i+1] = isnArray.arguments[i]; Because of the worldwide use of these drugs and the recently synthesized xanthine derivatives, an intensive research on the cardiac actions of these substances is under progress. Mechanism of Action. The increase in cAMP causes relaxation of bronchial smooth muscle. a. google_ad_channel ="6145589847"; The xanthine derivatives directly relax the smooth muscle surrounding the bronchial tubes (air passages) of the lungs, allowing the tubes to widen, making breathing easier. Pathology. Acute asthma attacks (status asthmaticus) are a medical emergency and are not rapidly responsive to usual doses of conventional bronchodilators. today=new Date(); These are plant alkaloids and components of coffee, tea and chocolate. Therapeutic Categories. Acta Pharmacol Toxicol (Copenh). Xanthine derivatives, including caffeine, prevent adenosine, hexobendine and regadenoson from working. It is claimed: 1. No. Possible side effects include: Digestive Tract: Stomach pain; nausea; vomiting; vomiting of blood; diarrhea; gastroesophageal reflux (nocturnal). These are very closely related and are to be found in extremely varying contents in different plants. Note that dyphylline is not converted to theophylline; thus, theophylline blood levels cannot be used to monitor its use. Dyphylline is not recommended for cl1idren. google_color_bg = "B2BABD"; HEALTH CARE | ABOUT US | CONTACT US | BLOG. If you cannot comply with this regimen, talk to your doctor about alternative therapy. The present invention relates to pharmaceutical formulations comprising xanthine or xanthine derivatives, kits thereof, and methods for treating fibrotic diseases by local administration. Therapy frequently requires IV medication and close monitoring .These products alone are not appropriate treatment for an acute asthma attack. J Pharm Pharmacol. Xanthine: A substance found in caffeine, theobromine, and theophylline and encountered in tea, coffee, and the colas. The novel xanthine compounds are capable of inhibiting tryptophan hydroxylases (TPH) involved in the biosynthesis of … Consult your doctor before you begin breastfeeding. Theophylline relaxes bronchial smooth muscle by inhibition of the enzyme phosphodiesterase and suppresses airway responsiveness to stimuli that cause bronchoconstriction. Methods: Plant extracts containing xanthine derivatives and three xanthine derivatives were topically applied to the dorsal skin of hairless mice, and the mice were exposed to a resemblance of solar ultraviolet irradiation at a dose of 13.0 J/cm(2) (UVA) for 15 weeks, five times a week on weekdays. 1988 Aug;94(4):1091-100. doi: 10.1111/j.1476-5381.1988.tb11627.x. The vasodilation caused by xanthines has been used to treat intermittent claudication (pentoxifylline).Xanthines also stimulate muscle and cardiac cells and neurons. Xanthine Derivative Bronchodilators: Adverse Reactions •CNS reactions These agents are used as additional therapy for patients who remain in refractory status asthmaticus despite maximal inhalational therapy and the use of corticosteroids. 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